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1

Biosynthesis of the Antibiotic Echinosporin by a Novel Branch of the Shikimate Pathway

Anke Dübeler, Philipp Krastel, Heinz G. Floss, Axel Zeeck

Journal:

European Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 237 KB

english, 2002

2

Biosynthesis of ergot alkaloids and related compounds

Journal:

Year:

1976

Language:

english

File:

PDF, 3.61 MB

english, 1976

3

Combinatorial biosynthesis—Potential and problems

Journal:

Journal of Biotechnology

Year:

2006

Language:

english

File:

PDF, 1.18 MB

english, 2006

4

RifamycinMode of Action, Resistance, and Biosynthesis

Floss, Heinz G., Yu, Tin-Wein

Journal:

Chemical Reviews

Year:

2005

Language:

english

File:

PDF, 445 KB

english, 2005

5

An antifungal compound from Solanum nigrescens

He, Xian-guo, Mocek, Ursula, Floss, Heinz G., Cáceres, Armando, Girón, Lidia, Buckley, Helen, Cooney, Gerard, Manns, Joanne, Wilson, Bary W.

Journal:

Journal of Ethnopharmacology

Year:

1994

Language:

english

File:

PDF, 397 KB

english, 1994

6

Synthesis of Ergot Alkaloids by Protoplasts of Claviceps Species

Robbers, James E., Cheng, Li-jung, Anderson, John A., Floss, Heinz G.

Journal:

Journal of Natural Products

Year:

1979

Language:

english

File:

PDF, 253 KB

english, 1979

7

Cover Picture

Anke Dübeler, Philipp Krastel, Heinz G. Floss, Axel Zeeck

Journal:

European Journal of Organic Chemistry

Year:

2002

File:

PDF, 117 KB

2002

8

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton

Journal:

Angewandte Chemie

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

9

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

10

Untersuchungen zur Biosynthese von Antibiotica

Prof. Dr. Heinz G. Floss, Prof. Dr. John M. Beale

Journal:

Angewandte Chemie

Year:

1989

Language:

german

File:

PDF, 3.06 MB

german, 1989

11

Biosynthetic Studies on Antibiotics

Prof. Heinz G. Floss, Prof. John M. Beale

Journal:

Angewandte Chemie International Edition

Year:

1989

Language:

english

File:

PDF, 2.98 MB

english, 1989

12

The Interplay between Mutasynthesis and Semisynthesis: Generation and Evaluation of an Ansamitocin Library

Dr. Simone Eichner, Dr. Tobias Knobloch, Prof. Heinz G. Floss, Jörg Fohrer, Dr. Kirsten Harmrolfs, Jekaterina Hermane, Anne Schulz, Dr. Florenz Sasse, Prof. Dr. Peter Spiteller, Dr. Florian Taft, Prof

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 665 KB

english, 2012

13

Über die Umlagerung einiger Phenyl-dihydroxy-aceton- und Phenyl-chlor-hydroxy-aceton-Derivate in Benzylglyoxal und Methyl-phenyl-glyoxal

Friedrich Weygand, Helmut Simon, Heinz-Günter Floss

Journal:

European Journal of Inorganic Chemistry

Year:

1961

Language:

german

File:

PDF, 566 KB

german, 1961

14

Determination of the Cryptic Stereochemistry of the First PKS Chain-Extension Step in Ansamitocin Biosynthesis by Actinosynnema pretiosum

Takaaki Kubota, Marco Brünjes, Thomas Frenzel, Jun Xu, Andreas Kirschning, Heinz G. Floss

Journal:

Year:

2006

Language:

english

File:

PDF, 122 KB

english, 2006

15

Highly Active Ansamitocin Derivatives: Mutasynthesis Using an AHBA-Blocked Mutant

Florian Taft, Marco Brünjes, Heinz G. Floss, Nadine Czempinski, Stephanie Grond, Florenz Sasse, Andreas Kirschning

Journal:

Year:

2008

Language:

english

File:

PDF, 236 KB

english, 2008

16

New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

Simone Eichner, Heinz G. Floss, Florenz Sasse, Andreas Kirschning

Journal:

Year:

2009

Language:

english

File:

PDF, 210 KB

english, 2009

17

Cyclization of Synthetic seco-Proansamitocins to Ansamitocin Macrolactams by Actinosynnema pretiosum as Biocatalyst

Dr. Kirsten Harmrolfs, Dr. Marco Brünjes, Dr. Gerald Dräger, Prof. Dr. Heinz G. Floss, Dr. Florenz Sasse, Dr. Florian Taft, Prof. Dr. Andreas Kirschning

Journal:

Year:

2010

Language:

english

File:

PDF, 261 KB

english, 2010

18

N-Methylation of the Amide Bond by Methyltransferase Asm10 in Ansamitocin Biosynthesis

Dr. Yingying Wu, Qianjin Kang, Dr. Guangdong Shang, Peter Spiteller, Brian Carroll, Tin-Wein Yu, Prof. Wenjin Su, Dr. Linquan Bai, Prof. Heinz G. Floss

Journal:

Year:

2011

Language:

english

File:

PDF, 686 KB

english, 2011

19

ChemInform Abstract: Synthesis of (-)-3-Amino-3-deoxyquinic Acid.

Michael Mueller, Rolf Mueller, Tin-Wein Yu, Heinz G. Floss

Journal:

Year:

1999

File:

PDF, 32 KB

1999

20

ChemInform Abstract: New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis.

Yiding Hu, Heinz G. Floss

Journal:

Year:

2001

File:

PDF, 24 KB

2001

21

ChemInform Abstract: Biosynthesis of the Antibiotic Echinosporin by a Novel Branch of the Shikimate Pathway.

Anke Duebeler, Philipp Krastel, Heinz G. Floss, Axel Zeeck

Journal:

Year:

2002

File:

PDF, 24 KB

2002

22

Recent Developments in the Maytansinoid Antitumor Agents

John M. Cassady, Kenneth K. Chan, Heinz G. Floss, Eckhard Leistner

Journal:

Year:

2004

File:

PDF, 52 KB

2004

23

Rifamycin — Mode of Action, Resistance, and Biosynthesis

Heinz G. Floss, Tin-Wein Yu

Journal:

Year:

2005

File:

PDF, 8 KB

2005

24

ChemInform Abstract: The Biosynthesis of 3-Amino-5-hydroxybenzoic Acid (AHBA), the Precursor of mC7N Units in Ansamycin and Mitomycin Antibiotics

Heinz G. Floss, Tin-Wein Yu, Kenji Arakawa

Journal:

Year:

2011

File:

PDF, 18 KB

2011

25

Synthesis of D-(-)-[1,7-13C2]shikimic acid

Hyeongjin Cho, Lutz Heide, Heinz G. Floss

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1992

Language:

english

File:

PDF, 255 KB

english, 1992

26

Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry

Zhongfa Liu, Heinz G. Floss, John M. Cassady, Kenneth K. Chan

Journal:

Journal of Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 243 KB

english, 2005

27

Steric course of the N-methylation in the biosynthesis of ergot alkaloids by Claviceps purpurea

Prof. Dr. Detlef Gröger, Lisa Gröger, Derin D'Amico, Min-Xia He, Heinz G. Floss

Journal:

Journal of Basic Microbiology

Year:

1991

Language:

english

File:

PDF, 360 KB

english, 1991

28

Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae

Kevin Reynolds, Jennifer Martin, Shu-Jane Shen, Nobuyoshi Esaki, Kenji Soda, Prof. Dr. Heinz G. Floss

Journal:

Journal of Basic Microbiology

Year:

1991

Language:

english

File:

PDF, 830 KB

english, 1991

29

Biosynthesis of pyrrolnitrin. Incorporation of 13C, 15N double-labelled D- and L-tryptophan

Pei Zhou, Ursula Mocek, Brian Siesel, Prof. Dr. Heinz G. Floss

Journal:

Journal of Basic Microbiology

Year:

1992

Language:

english

File:

PDF, 399 KB

english, 1992

30

Nidation inhibition by simple ergoline derivatives

Karel Řežábek, John M. Cassady, Heinz G. Floss

Journal:

Journal of Pharmaceutical Sciences

Year:

1975

Language:

english

File:

PDF, 199 KB

english, 1975

31

Stereochemistry and mechanism of the GDP-mannose dehydratase reaction

Philip J. Oths, Robert M. Mayer, Heinz G. Floss

Journal:

Carbohydrate Research

Year:

1990

Language:

english

File:

PDF, 692 KB

english, 1990

32

Structural determination of alginic acid and the effects of calcium binding as determined by high-field n.m.r.

Cora A. Steginsky, John M. Beale, Heinz G. Floss, Robert M. Mayer

Journal:

Carbohydrate Research

Year:

1992

Language:

english

File:

PDF, 1.09 MB

english, 1992

33

Synthesis of 4-amino 3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate, the biosynthetic precursor of C7N units in ansamycin antibiotics

Andreas Kirschning, Philippe Bergon, Jeh-Jeng Wang, Steven Breazeale, Heinz G. Floss

Journal:

Carbohydrate Research

Year:

1994

Language:

english

File:

PDF, 956 KB

english, 1994

34

Synthesis of [6″-3H]-, (6″-2H)- and (2-2H)-maltotriose

Bernd Sauerbrei, Jutta Niggemann, Stefan Gröger, Sungsook Lee, Heinz G. Floss

Journal:

Carbohydrate Research

Year:

1996

Language:

english

File:

PDF, 698 KB

english, 1996

35

Development of triple-quantum “INADEQUATE” for biosynthetic studies

John M Beale, Charles E Cottrellt, Paul J Keller, Heinz G Floss

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 298 KB

english, 1969

36

Evidence supporting the formation of a substrate radical during H2O2-coupled MMO catalyzed oxidation of chiral ethane

Wayne A. Froland, Nigel D. Priestley, Heinz G. Floss, Philip G. Williams, Hiromi Morimoto, John D. Lipscomb

Journal:

Journal of Inorganic Biochemistry

Year:

1993

Language:

english

File:

PDF, 100 KB

english, 1993

37

Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety

Nigel D. Priestley, Todd M. Smith, Paul R. Shipley, Heinz G. Floss

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 1.28 MB

english, 1996

38

Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A

Linquan Bai, Lei Li, Hui Xu, Kazuyuki Minagawa, Yi Yu, Yirong Zhang, Xiufen Zhou, Heinz G. Floss, Taifo Mahmud, Zixin Deng

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 411 KB

english, 2006

39

Amide N-Glycosylation by Asm25, an N-Glycosyltransferase of Ansamitocins

Peiji Zhao, Linquan Bai, Juan Ma, Ying Zeng, Lei Li, Yirong Zhang, Chunhua Lu, Huanqin Dai, Zhaoxian Wu, Yaoyao Li, Xuan Wu, Gang Chen, Xiaojiang Hao, Yuemao Shen, Zixin Deng, Heinz G. Floss

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

40

An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics

Zhongfa Liu, Heinz G. Floss, John M. Cassady, Jim Xiao, Kenneth K. Chan

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2004

Language:

english

File:

PDF, 138 KB

english, 2004

41

Biosynthetic studies on the α-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-α-d-glucose

Simeon G. Bowers, Taifo Mahmud, Heinz G. Floss

Journal:

Carbohydrate Research

Year:

2002

Language:

english

File:

PDF, 164 KB

english, 2002

42

On the biosynthesis of furocoumarins in Pimpinella magna

Heinz-Günter Floss, Ute Mothes

Journal:

Year:

1966

Language:

english

File:

PDF, 669 KB

english, 1966

43

Incorporation of shikimic acid into p-hydroxybenzoic acid in Lithospermum erythrorhizon cell cultures

Lutz Heide, Heinz G. Floss, Mamoru Tabata

Journal:

Year:

1989

Language:

english

File:

PDF, 193 KB

english, 1989

44

Genetic engineering of hybrid antibiotics - a progress report

Heinz G. Floss, William R. Strohl

Journal:

Year:

1991

Language:

english

File:

PDF, 1.00 MB

english, 1991

45

Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase

David C Williams, Brian J Carroll, Qingwu Jin, Christopher D Rithner, Steven R Lenger, Heinz G Floss, Robert M Coates, Robert M Williams, Rodney Croteau

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 385 KB

english, 2000

46

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699

Paul R. August, Li Tang, Yeo J. Yoon, Sandra Ning, Rolf Müller, Tin-Wein Yu, Matthew Taylor, Dietmar Hoffmann, Chun-Gyu Kim, Xiaohong Zhang, C. Richard Hutchinson, Heinz G. Floss

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 2.98 MB

english, 1998

47

The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host

Koji Ichinose, David J. Bedford, Diethild Tornus, Andreas Bechthold, Maureen J. Bibb, W. Peter Revill, Heinz G. Floss, David A. Hopwood

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 1.43 MB

english, 1998

48

Lessons from the rifamycin biosynthetic gene cluster

Heinz G Floss, Tin-Wein Yu

Journal:

Current Opinion in Chemical Biology

Year:

1999

Language:

english

File:

PDF, 183 KB

english, 1999

49

The biosynthesis of acarbose and validamycin

Taifo Mahmud, Sungsook Lee, Heinz G. Floss

Journal:

The Chemical Record

Year:

2001

Language:

english

File:

PDF, 418 KB

english, 2001

50

Über den Einfluß von Tryptophan und analogen Verbindungen auf die Biosynthese von Clavinalkaloiden in saprophytischer Kultur

Heinz-Günter Floss, Ute Mothes

Journal:

Archives of Microbiology

Year:

1964

Language:

german

File:

PDF, 554 KB

german, 1964